Association of metformin use with primary open-angle glaucoma using data from the National Institutes of Health <i>All of Us</i> Program.

ABSTRACT:

Background

Few studies have assessed the impact of metformin use on glaucoma risk. The purpose of this study was to examine the association between metformin use and the incidence of primary open-angle glaucoma (POAG) in a diverse and large nationwide cohort.

Methods

We included a retrospective cohort study of 18 440 participants in the National Institutes of Health All of Us Research Program aged 40 years or older, with a diagnosis of diabetes mellitus and without a diagnosis of POAG prior to diabetes diagnosis or metformin use. Bivariate logistic regression, multivariable logistic regression and survival analysis were used to analyse the association between ever use of metformin and incidence of POAG.

Results

Within the cohort, 240 participants acquired a dia

SUBMITTER: Sidhu S 

PROVIDER: S-EPMC12519326 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature