Exploring potential target drugs for vision-threatening diabetic retinopathy using the human plasma proteome: a Mendelian randomisation study.

ABSTRACT:

Background

Diabetic retinopathy (DR) is a common microvascular complication of diabetes that has the potential to progress to vision-threatening DR (VTDR) even in the absence of symptoms. Plasma proteins in response to physiological and pathological conditions in the body may be intricately connected to the initiation of VTDR.

Objective

To determine the causality between 4489 plasma proteins and the risk of VTDR to explore potential therapeutic targets for VTDR.

Design

A Mendelian randomisation (MR) study.

Setting

A two-sample MR study was performed to investigate the causality between plasma proteins and VTDR.

Participants

Genetic information on plasma proteins and VTDR in European populations from IEU OpenGWAS.

Primary and secondary outcome measures

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12519383 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature