Biomimetic Total Synthesis of (±)-Lappaceolides A and B.

ABSTRACT: The first total synthesis of lappaceolides A and B is achieved in two steps by using a biomimetic vinylogous-Michael-oxa-Michael domino reaction. The domino reaction proceeds with Cs₂CO₃ in 1,2-DCE at elevated temperatures and requires careful kinetic control. The total synthesis provides further proof of the biosynthetic hypothesis of lappaceolides being dimers of the natural product siphonodin.

SUBMITTER: Pallerla RR 

PROVIDER: S-EPMC12519463 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature