Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II.

ABSTRACT: In this work, we report on the completion of the total synthesis of jaspine B from Garner's aldehyde using a Pd-catalyzed carbonylation strategy under continuous flow conditions. The target compound was synthesized from the key intermediate bicyclic aminolactone 5 via a sequence of Wittig olefination, DiBAl-H reduction, and hydrogenation, all implemented in flow microreactors. A particularly efficient transfer hydrogenation of the C ═ C double bond in alkene 8 was achieved by using formic acid as the hydrogen donor and palladium immobilized within a urea-based polymer support (UBPS). Furthermore, a multistep flow system was developed, enabling the direct integration of the hydrogenation of alkene 8 with the final carbamate 9 deprotection step. The methodology wa

SUBMITTER: Gursky M 

PROVIDER: S-EPMC12519474 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature