Copper-Catalyzed Diastereoselective Defluoroborylation of Pentafluoroethyl Alkenes Using (pin)B-B(dan).

ABSTRACT: We herein describe a highly diastereoselective Cu(I)-catalyzed defluoroborylation of pentafluoroethyl alkenes using a diboron reagent (pin)B-B(dan). When 1,1- or 1,2-disubstituted pentafluoroethyl alkenes are employed as substrates, tetra- or trisubstituted fluoroalkenes can be obtained, respectively, in up to >99:1 diastereoselectivity. This protocol provides access to novel allyl-B(dan) compounds and allylic alcohols with alkene moieties containing F and CF₃ on the same carbon.

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12519480 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature