Association Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.

ABSTRACT:

Background

Sarcopenia and intervertebral disc degeneration (IDD) are both highly prevalent among the elderly and have a substantial impact on their quality of life. However, the association between sarcopenia and IDD remains unclear. This study aimed to investigate whether sarcopenia is independently associated with an increased risk of IDD in middle-aged and older adults, using prospective data from the UK Biobank.

Methods

A total of 378 773 participants from the UK Biobank were included and categorized into three groups based on the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria: normal, probable sarcopenia and confirmed sarcopenia. The association between sarcopenia and IDD was examined using Kaplan-Meier survival analysis and Cox proportional h

SUBMITTER: Chen J 

PROVIDER: S-EPMC12519499 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature