Independent effects of white matter lesion volume and APOE ɛ4 on ARIA-H in A4 Study.

ABSTRACT:

Introduction

Increased white matter hyperintensity (WMH) volume is a common but non-specific finding in AD. This study investigates the effect of baseline WMH volume and APOE ε4 on magnetic resonance imaging (MRI)-visible hemorrhagic lesion emergence.

Methods

We included A4 participants with 0/1 hemorrhagic lesion at baseline and >1 post-baseline MRI. We examined age, sex, amyloid, WMH, APOEε4, and cardiovascular risk as predictors of whether people would accrue ≥2 hemorrhagic lesions by their last MRI.

Results

Among 1097 individuals with 0/1 baseline lesion, 120 had at least two hemorrhagic lesions on their last MRI. Elevated baseline WMH (odds ratio [OR] = 2.3, p = 0.002) and APOE ɛ4/ɛ4 (OR = 4.8, p < 0.001) independently predicted membership to this group. Both het

SUBMITTER: Shirzadi Z 

PROVIDER: S-EPMC12519508 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature