Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning.

ABSTRACT:

Introduction

The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear.

Methods

We analyzed data from 1323 individuals without a diagnosis of dementia (CDR < 1) with T1w-MRI and amyloid-PET, including 622 with longitudinal data (3.66 ± 1.78 years). Cortical thickness subtypes were identified using a non-negative matrix factorization (NMF) clustering algorithm. We examined clinical and demographic differences, subtype stability, and longitudinal thinning patterns using brain network models and imaging-transcriptomic analysis. Replication was performed with an alternative clustering approach and a validation cohort.

Results

Two stable subtypes emerged: limbic-predominant and hippocampal-sparing. Limbic-predominant

SUBMITTER: Lorenzini L 

PROVIDER: S-EPMC12519513 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature