Impact of kidney function on biomarkers of neurodegeneration, white matter hyperintensities, and cognition in older adults.

ABSTRACT:

Background

We evaluated the association between kidney function, neurodegenerative biomarkers (i.e., neurofilament light chain [NfL], total tau [t-tau], and glial fibrillary acidic protein [GFAP]), white matter hyperintensities, and global cognition.

Methods

The study consisted of 1207 participants living on the south side of Chicago, Illinois, enrolled in the Chicago Health and Aging Project, a population-based cohort since 1993. Kidney function was assessed using the estimated glomerular filtration rate (eGFRcr), calculated according to the 2021 Chronic Kidney Disease Epidemiology (CKD-EPI) based on age, sex, and serum creatinine levels.

Results

In a multivariable-adjusted model, lower levels of eGFRcr were associated with higher levels of biomarkers of neurodegener

SUBMITTER: Dhana A 

PROVIDER: S-EPMC12519524 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature