The association of human apolipoprotein ε4 with dementia, cognition, imaging, and plasma biomarkers of neurodegeneration in a sample of older adults in the Democratic Republic of the Congo.

ABSTRACT:

Introduction

This study examined the association between the apolipoprotein E (APOE) ε4 allele and cognitive performance, neuroimaging, and plasma biomarkers in Congolese older adults in the Democratic Republic of the Congo (DRC).

Methods

Eighty-four participants (39 healthy controls [HCs], 45 with suspected dementia), aged 73.0 years on average, were assessed using the African Neuropsychology Battery, magnetic resonance imaging, and blood-based biomarkers. Regression models adjusted for age, sex, and education evaluated APOE's impact.

Results

APOE ε4 was more prevalent in dementia cases than in HCs. Overall, APOE ε4 status significantly affected naming and memory scores, mesial temporal and entorhinal cortex atrophy scores, and glial fibrillary acidic protein concent

SUBMITTER: Ikanga J 

PROVIDER: S-EPMC12519526 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature