Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage.

ABSTRACT: Intracerebral haemorrhage (ICH) is a devastating stroke subtype lacking effective therapies. Understanding key pathological processes related to acute brain damage will help deliver better outcomes for ICH. Herein, we provide evidence that myeloid cell trafficking to the parenchyma is a conserved feature of ICH in clinical and experimental settings. Consistent with others, we show that monocytes contribute to acute brain damage following collagenase-induced murine ICH. Using RNA sequencing, we identified the pro-inflammatory cytokine interleukin-1 (IL-1) as a potential upstream regulator of the acute inflammatory response, with histological data pinpointing mononuclear phagocytes as the principal cellular source of IL-1 in patient and animal tissue. In agreement, inhibition of IL-1 recepto

SUBMITTER: Barrington J 

PROVIDER: S-EPMC12519545 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature