Meta-omics reveals subgingival plaque reconstruction dynamics.

ABSTRACT:

Background

The homeostasis of the subgingival microbiome is crucial for periodontal health, although the dynamics governing its community variation remain insufficiently studied. This study aims to investigate the dynamics of subgingival microbiota reassembly after disruption, focusing on core taxa, functions, and driving forces.

Methods

339 subgingival plaques in periodontally healthy states were collected before and after ultrasonic cleaning across 12 timepoints for 1 year. All samples underwent full-length 16S rRNA sequencing; 30 were selected for metagenomic sequencing.

Results

Our findings revealed that disturbed subgingival microbiota underwent short-term disruptions but subsequently reverted to baseline, maintaining stability within a year. Homogeneous selectio

SUBMITTER: Zhou F 

PROVIDER: S-EPMC12519584 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature