Association between blood-derived biological aging and bone mineral density among US adults.

ABSTRACT:

Objective

Little is known regarding the association between biological aging and bone mineral density (BMD). This study aimed to assess the effects of biological aging on BMD in US adults.

Methods

This study included 14,499 adults aged 20 or older from NHANES (2005-2010, 2013-2014, and 2017-2018). Biological aging was assessed using two different approaches: biological age and biological age acceleration. Multiple linear regression was used to investigate the relationship between biological aging and BMD. Generalized additive models and smoothed curve fitting were used to examine the dose-response relationship between biological aging and BMD. Multiple logistic regression was used to investigate the relationship between biological aging and the risk of osteoporosis.

Resul

SUBMITTER: Wu L 

PROVIDER: S-EPMC12519605 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature