Association between pro-inflammatory proteins and neurofilament in plasma from persons with epilepsy.

ABSTRACT:

Background

Inflammation and neurodegeneration are emerging as pathophysiological processes of interest in epilepsy. Seizures can both arise from and induce inflammation and difficult-to-treat epilepsy is linked to brain atrophy. However, the interplay between inflammation and neurodegeneration remains poorly understood in epilepsy. This study investigates the association between inflammatory proteins and plasma neurofilament light chain (NEFL or NfL), a known marker of neurodegeneration, particularly in relation to active epilepsy.

Methods

We performed Olink proteomics on plasma from 176 epilepsy patients aged between 18 and 50 years. To assess systemic inflammation, a composite pro-inflammatory score was derived from the expression of 12 pro-inflammatory proteins. Patients

SUBMITTER: Sarangdhar M 

PROVIDER: S-EPMC12519617 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature