Programmable macrophage-polarizing nanoparticles for MRI-guided early detection and treatment of pulmonary metastases.

ABSTRACT: Metastatic lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the urgent need for early detection and intervention strategies. Current diagnostic and therapeutic methods often fall short in sensitivity and efficacy, particularly for early-stage disease. In this study, we develop CaCO₃@quercetin-Mn nanoparticles (CQM NPs) integrating dual-stage macrophage reprogramming with T₁-weighted magnetic resonance imaging (MRI) enhancement for theranostic management of pulmonary metastasis. CQM NPs exploit dynamic macrophage polarization: initial M2 polarization promotes nanoparticles accumulation in metastatic lesions, enabling detection of lesions as small as 0.11 mm, while subsequent acid/glutathione (GSH)-triggered degradation reprograms

SUBMITTER: Sui M 

PROVIDER: S-EPMC12519618 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature