Epidemiology of early-onset and late-onset invasive infections in Australian neonates and infants: a retrospective multicentre study.

ABSTRACT:

Background

There has been little decline in neonatal mortality rates over recent decades, and this is now further challenged by the rising prevalence of antimicrobial resistance. In Australia, the incidence of neonatal sepsis is low on a global scale, yet there are increasingly frequent outbreaks of multidrug-resistant (MDR) infections in neonatal intensive care units, alongside rising rates of colonisation with MDR bacteria.

Methods

We analysed positive blood and cerebrospinal fluid cultures collected from infants (aged 0 to ≤180 days) across five clinical sites in Australia between 2010 and 2019, to determine evolving antimicrobial susceptibility profiles.

Results

After excluding presumed contaminants, we analysed 743 pathogenic bacterial isolates cultured from 624

SUBMITTER: Williams PCM 

PROVIDER: S-EPMC12519648 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature