Physical activity and the risk of cardiovascular disease, cirrhosis, cancer and mortality among individuals with MASLD: a prospective cohort study.

ABSTRACT:

Objectives

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue due to its high prevalence, yet the impact of accelerometer-measured physical activity on clinical outcomes remains unclear. This study aims to examine the associations of physical activity with the risk of liver cirrhosis, cancer, cardiovascular disease (CVD) incidence and mortality.

Methods

32 681 MASLD participants with accelerometer-derived physical activity data from the UK Biobank were analysed. Physical activity intensity was categorised into light (LPA), moderate (MPA) and vigorous (VPA) intensity. Cox proportional hazard and acceleration failure models were employed to assess associations between physical activity duration and outcomes.

Results

During a median

SUBMITTER: Xu S 

PROVIDER: S-EPMC12519692 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature