Greater lung cancer polygenic risk score in higher air pollution areas linked to greater rate of lung adenocarcinoma: a single-centre study in East Asia.

ABSTRACT:

Background

Lung cancer, a leading cause of cancer deaths, is influenced by smoking, air pollution and genetic factors. This study investigated the association between lung cancer polygenic risk score (PRS) and air pollution in lung adenocarcinoma (LUAD) cases in East Asia.

Methods

This Taiwanese case-control study included 57 257 participants, of whom 1059 were diagnosed with lung cancer and 857 had LUAD. Excluding individuals with missing PRS data, the final study group comprised 648 LUAD patients and 6480 age- and gender-matched controls. Logistic regression models were employed to assess the association between PRS and LUAD risk, and interaction effects between PRS and particulate matter (PM2.5/PM10) exposure were evaluated.

Results

PGS000070 demonstrated an OR of

SUBMITTER: Chang SL 

PROVIDER: S-EPMC12519728 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature