Detoxification of domoic acid from Pseudo-nitzschia by gut microbiota in Acartia erythraea.

ABSTRACT: Domoic acid (DA) is a neurotoxin produced by certain species of Pseudo-nitzschia (PSN) that can cause damage to neural tissues and can be fatal to marine animals. Copepods, direct consumers of PSN, exhibit remarkable resistance to DA. Given that gut microbiota facilitate various detoxification processes in copepods, we hypothesize that gut microbiota may play a crucial role in aiding copepods in DA detoxification. In this study, we investigated the detoxification capability of copepod gut microbiota by feeding both wild-type and gut-microbiota-free Acartia erythraea toxic PSN. Our results demonstrated that the presence of gut microbiota enhanced the survival of copepods exposed to a DA diet. We subsequently feed A. erythraea both toxic and non-toxic PSN, and explored the potential mechanis

SUBMITTER: Li Q 

PROVIDER: S-EPMC12519767 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature