Proof-of-concept study on Bruch's membrane opening minimum rim width (BMO-MRW) and optic nerve head morphology in people living with HIV.

ABSTRACT:

Background

HIV and antiretroviral therapy (ART) are known to affect ocular health, yet the impact on optic nerve head parameters remains underexplored. This study investigates ONH structural parameters in HIV-positive adults using a novel Bruch's Membrane Opening-Minimum Rim Width (BMO-MRW) method, which offers a precise assessment of ONH integrity.

Methods

There were 62 eyes of HIV on ART (HIV-ART), 20 eyes of HIV not on ART (HIV-N-ART), and 82 HIV negative healthy controls (HIV controls). Participants underwent Optical Coherence Tomography to measure optic nerve head morphology using Bruch's Membrane Opening Minimum Rim Width protocol. Generalized estimating equations and effect size calculations compared thickness differences between groups. Multivariable regression and o

SUBMITTER: Buthelezi LM 

PROVIDER: S-EPMC12519773 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature