Myeloid cell-specific type I interferon signaling mediates age-dependent inflammation and protection in <i>Bordetella pertussis</i> infection.

ABSTRACT: Type I interferons (IFNs) play complex roles during bacterial infections. We previously found that type I IFNs were induced in Bordetella pertussis-infected adult mice but not in infant mice, a potentially relevant clinical dichotomy, since pertussis can be fatal in human infants. We investigated the role of type I IFNs and their cross-regulation with type III IFNs (IFN-λ) in B. pertussis infection across developmental stages. In contrast to global IFNAR1 knockout adult mice, in which lung inflammation was equivalent to that in wild-type mice, myeloid cell-specific deficiency of the type I IFN receptor protein IFNAR1 (LysM^CreIFNAR1^fl/fl) resulted in significantly reduced lung inflammation and pro-inflammatory cytokine production, despite elevated pulmona

SUBMITTER: Kumar A 

PROVIDER: S-EPMC12519780 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature