Modulation of group B <i>Streptococcus</i> infection and vaginal cell inflammatory signaling <i>in vitro</i> by <i>Lactobacillus crispatus</i>-loaded electrospun fibers.

ABSTRACT: Vaginal colonization by Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a major risk factor for ascending infections, preterm birth, and neonatal sepsis. Current GBS prevention efforts include routine GBS perinatal screening and intrapartum antibiotic prophylaxis, which decrease the rate of early-onset neonatal sepsis, but have drawbacks that include impacting the infant's developing microbiome. Lactobacillus-dominant vaginal microbiomes provide protection against pathogens such as GBS, and using probiotics as an antibiotic-free approach to limit GBS colonization is of increasing interest. In this study, we investigated the ability of Lactobacillus crispatus-loaded electrospun fibers to deliver live L. crispatus cells in an in v

SUBMITTER: El-Baz N 

PROVIDER: S-EPMC12519788 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature