Genetic transformation of <i>Gardnerella</i> species and characterization of vaginolysin and sialidase mutants.

ABSTRACT: Bacterial vaginosis (BV) is the most prevalent vaginal disorder in women of childbearing age and causes pregnancy complications, including preterm birth, amnionitis, and postpartum endometritis. BV also interferes with sexual health and increases stress. BV is a vaginal dysbiosis that occurs when Lactobacillus species are displaced by facultative and anaerobic bacterial species, including Gardnerella, Prevotella, Fannyhessea, Sneathia, Megasphaera, Mycoplasma, and others. Species of Gardnerella increase just prior to the onset of symptoms and are considered to play major roles in the development and transmission of BV. However, Gardnerella species have remained genetically intractable, limiting investigations of their virulence mechanisms. Here, we describe meth

SUBMITTER: Klimowicz AK 

PROVIDER: S-EPMC12519793 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature