Mouse monoclonal antibodies against <i>Clostridioides difficile</i> toxins TcdA and TcdB target diverse epitopes for neutralization.

ABSTRACT: Clostridioides difficile is a spore-forming, Gram-positive bacterium that can cause infections in subjects with weakened immune system or following antibiotic treatment. These infections may lead to pseudomembranous colitis and antibiotic-associated diarrhea in humans. As such, C. difficile is a major cause of nosocomial illness worldwide. Major virulence factors of the bacterium are the large clostridium toxins A (TcdA) and B (TcdB)-high molecular mass proteins with intrinsic glucosyltransferase activity. Toxins bind to the intestinal epithelium and undergo endocytosis by the epithelial cells, followed by a conformational change triggered by the low pH of early endosomes. This conformational change leads to the exposure of hydrophobic segments, followed by membrane insertion

SUBMITTER: Kroh HK 

PROVIDER: S-EPMC12519798 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature