AHSA1 as a prognostic biomarker and potential immunotherapeutic target in HNSCC: integrative bulk RNA-seq, scRNA-seq analyses and experimental validation.

ABSTRACT:

Background

Heat shock 90 kDa protein ATPase homolog 1 (AHSA1), a chaperone of heat shock protein 90 (Hsp90), is upregulated in various malignancies, where it promotes the invasion, migration, and proliferation of cancer cells. Nevertheless, the precise function of AHSA1 in head and neck squamous cell carcinoma (HNSCC) has yet to be investigated.

Methods

To comprehensively investigate AHSA1 profiles of expression in HNSCC, various techniques including bioinformatics analysis of public databases and qRT-PCR were utilized. To evaluate AHSA1's clinical significance in HNSCC, survival analysis was performed using Cox regression models and Kaplan-Meier curves. The associations between AHSA1 expression, immune microenvironment characteristics, and drug sensitivity were analyzed thr

SUBMITTER: Gu F 

PROVIDER: S-EPMC12519801 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature