Lymphotoxin beta receptor^-/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after <i>Toxoplasma gondii</i> infection.

ABSTRACT: Lymphotoxin β receptor (LTβR/TNFRSF3) signaling plays a crucial role in immune defense. Notably, LTβR-deficient (LTβR^-/-) mice exhibit severe defects in innate and adaptive immunity against various pathogens and succumb to Toxoplasma gondii infection. Here, we investigated the bone marrow (BM) and peritoneal cavity (PerC) compartments of LTβR^-/- mice during T. gondii infection, demonstrating perturbed B-cell and T-cell subpopulations in the absence of LTβR signaling. T. gondii infection disrupted BM lymphopoiesis, depleting early and mature B cells in WT mice, whereas mature B cells remained present in LTβR^-/- BM. LTβR^-/- BM also exhibited reduced MHCII⁺ monocytes and a plasma cell compartment skewed toward IgM

SUBMITTER: Helle M 

PROVIDER: S-EPMC12519803 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature