Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters.

ABSTRACT:

Background

Theoretical hypotheses suggest differing oxidative stress levels in mood disorders. We evaluated eight oxidative stress-related biochemical markers for further verification in first-onset patients with bipolar disorder (BD) or major depressive disorder (MDD).

Methods

We extracted 224 first-onset patients (BD = 93 and MDD = 131) from the overall sample database of 4647 candidates. And we analyzed eight parameters: direct bilirubin (DBIL), indirect bilirubin (IBIL), uric acid (UA), lactate dehydrogenase (LDH), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), prealbumin, and progesterone.The above parameters enter the hierarchical multiple linear regression model for analysis.

Results

When compared to MDD, the BD group showed decreased prealbumi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12519812 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature