Decellularized extracellular matrix bio-patch with strong and biodegradable wet adhesive interface for sutureless soft tissue defect repair.

ABSTRACT: Decellularized extracellular matrix-based bio-patches offer superior biocompatibility and bioactivity, making them an ideal implantation material for soft tissue defect repair. However, the fixation of these patches typically relies on sutures or staplers, causing secondary tissue damage, stress concentration, and excessive inflammatory cell infiltration. Here, we develop a novel self-adhesive small intestinal submucosa patch (A-SIS) fabricated by in situ polymerizing a biodegradable hydrogel adhesive layer on the surface of the SIS patch. The A-SIS demonstrated increased tensile strength, biodegradability, and strong wet adhesion to various soft tissues (including skin, heart, stomach, and intestine), with shear strength reaching 100 kPa and interfacial toughness of 700 J/m² fo

SUBMITTER: Chen X 

PROVIDER: S-EPMC12519820 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature