Fatal outcome of severe serotonin syndrome and acute respiratory distress syndrome after self-poisoning with paroxetine: a case report.

ABSTRACT:

Background

Paroxetine overdose can cause serotonin syndrome, presenting with a constellation of manifestations that range from mild symptoms to life-threatening complications. Current evidence regarding the management of paroxetine-induced serotonin syndrome is limited to case reports and small case series, with no definitive recommendations established from controlled clinical trials in humans.

Case presentation

In this case report, we describe an exceptional and severe clinical course of a 26-year-old Caucasian female who ingested multiple drugs with suicidal intention-including 4000 mg paroxetine. The patient developed severe serotonin syndrome complicated by acute respiratory distress syndrome, necessitating invasive mechanical ventilation and veno-venous extracorporeal

SUBMITTER: Putz SM 

PROVIDER: S-EPMC12519824 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature