A cost-effectiveness analysis of novel stool processing methods for diagnosis of tuberculosis in children under 5 years of age in Uganda.

ABSTRACT:

Background

Stool-based molecular assays for childhood tuberculosis (TB) diagnosis have shown promise as an alternative to respiratory sample testing. While implementation is underway, evidence on cost-effectiveness is needed. Therefore, we aimed to evaluate the costs of stool testing with Xpert Ultra and model the cost-effectiveness of implementation scenarios at lower levels of care.

Methods

We measured costs for three new stool processing methods: Simple One-Step (SOS), Stool Processing Kit, and Optimized Sucrose Flotation. Each method mixed stool with Xpert Sample Reagent buffer, incubated to allow sedimentation, and then dispensed the supernatant into the Xpert Ultra cartridge. While the other methods required additional buffer and supplies, SOS used only the Sample Reag

SUBMITTER: Gaeddert M 

PROVIDER: S-EPMC12519833 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature