Delabeling Antibiotic Allergy in the Solid Organ Transplant Population Using a Multiple Antibiotic Allergy Evaluation Strategy.

ABSTRACT:

Background

First-line antibiotics, such as penicillins, cephalosporins, and sulfonamides, are critical for preventing infections in immunocompromised solid organ transplant (SOT) patients. However, many patients are labeled with multiple antibiotic allergies (AALs) prior to transplant, increasing their risk of adverse outcomes. Because these patients often travel long distances and follow complex care plans, minimizing the number of drug allergy clinic (DAC) visits is important to avoid disruption and improve care continuity.

Methods

We conducted a retrospective cohort study of SOT patients evaluated at Vanderbilt University Medical Center outpatient DAC between 2014 and 2024. We assessed the efficacy, feasibility, and efficiency of a multiple antibiotic allergy evaluation s

SUBMITTER: Lee R 

PROVIDER: S-EPMC12519911 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature