Respiratory Viruses at Time of Lung Transplant and the Relationship to Primary Graft Dysfunction.

ABSTRACT:

Background

Primary graft dysfunction (PGD) is a form of immediate post-transplant acute lung injury associated with increased risk of mortality, and it is possible that respiratory viruses (RVs) at the time of transplant may augment this.

Methods

We retrospectively studied all adult lung transplant recipients transplanted in our program from 2017 to 2020, with a primary outcome of grade 3 PGD (PGD3), defined as edema on chest X-ray and arterial oxygen/fraction of inspired oxygen ratio <200 at 48- or 72-h post-transplant. RV status was assessed by nucleic acid amplification test on routine bronchoscopic specimens performed on day 1 post-transplant. During the pandemic, severe acute respiratory syndrome coronavirus 2 was sampled in all donors and recipients and precluded trans

SUBMITTER: van den Bosch L 

PROVIDER: S-EPMC12519916 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature