Adjustment of positive end-expiratory pressure based on body mass index during general anaesthesia: a randomised controlled trial.

ABSTRACT:

Introduction

Lung-protective ventilation is essential for preventing postoperative pulmonary complications. While maintaining a low driving pressure and optimising PEEP is of importance, the ideal strategy remains contentious. This study evaluated whether adjusting PEEP based on BMI, compared with standard PEEP, could reduce driving pressure and peri-operative loss of lung aeration.

Methods

We conducted a randomised controlled, patient-blinded, single-centre superiority trial with two parallel groups. Adult patients undergoing surgery with general anaesthesia who required tracheal intubation were assigned randomly to either standardised PEEP (PEEP = 5 cmH₂O; group PEEP-5) or PEEP set according to BMI (PEEP = BMI/3 cmH₂O; group PEEP-BMI/3). Patients' lun

SUBMITTER: Selpien H 

PROVIDER: S-EPMC12519930 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature