Manganese homeostasis modulates glucan and chitin unmasking in the opportunistic yeast <i>Candida albicans</i>.

ABSTRACT: Candida albicans is a commensal fungus and also the most prevalent human fungal pathogen. The ability of this opportunistic yeast to acquire and maintain homeostatic levels of manganese (Mn), particularly in the metal-limited host environment, is an important determinant of its fitness. Recent studies have underscored the importance of Mn acquisition through members of Smf transporters, in C. albicans virulence and its ability to withstand various stresses. In the present study, we undertook transcriptional profiling in the mutant of the Mn transporter Smf12 under restricted Mn availability to identify processes that are directly impacted by impaired Mn uptake. Our analysis revealed that smf12 displayed a transcriptional pattern suggestive of a cell wall defect, with m

SUBMITTER: Henry M 

PROVIDER: S-EPMC12520074 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature