LncRNA-CFTBS enhances <i>Mycobacterium tuberculosis</i> survival in macrophages by modulating ferroptosis through the miR-515-5p/miR-519e-5p/SAT1 axis.

ABSTRACT: Tuberculosis (TB) remains one of the primary global causes of death and poses substantial public health challenges. The intracellular survival of Mycobacterium tuberculosis (M.tb) can be influenced by ferroptosis; however, how lipid peroxidation-induced ferroptosis operates during M.tb infection remains unclear. Our study revealed a significantly upregulated lncRNA (lncRNA-cytoplasm-regulating ferroptosis and tuberculosis survival (CFTBS)) that modulates ferroptosis, enhancing M.tb intracellular survival by affecting the lipid peroxidation-related pathway rather than the cystine/GSH/GPX4 pathway. We elucidated that lncRNA-CFTBS competitively binds miR-515-5p and miR-519e-5p, regulating spermidine/spermine N1-acetyltransferase 1 (SAT1) expression, which plays a critical role in incre

SUBMITTER: Li Y 

PROVIDER: S-EPMC12520127 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature