Evaluation of Hyaluronic Acid Filler Injections in Mice Over 28 Days: A Controlled In Vivo Study.

ABSTRACT:

Background

Initial and early swelling post injection of hyaluronic acid (HA) filler are considered to affect outcomes and complications in patients; however, the contribution of HA filler type to swelling postinjection remains undetermined. Here, initial and early swelling post injection of HA fillers manufactured via different crosslinking technologies was evaluated in mice.

Methods

Mice received injections of HA fillers or controls: High Concentration Equalized (HICE), Stabilized High Concentration Equalized (S-HICE), High molecular Ideal, VYCROSS, NASHA, HICE control, non-HICE control, or no HA control. Initial and early swelling were evaluated via magnetic resonance imaging and collagen deposition via histological evaluation over 28 days.

Results

Mice (N = 65) wer

SUBMITTER: Jang WE 

PROVIDER: S-EPMC12520210 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature