The Aetiology of Elevated Total Serum Immunoglobulin E in Children.

ABSTRACT:

Aim

The paucity of real-world data on the aetiology of elevated total serum immunoglobulin E (TS-IgE) in children afflicts families and health care systems with diagnostic uncertainty. We explored a cohort of children with TS-IgE levels over 1000 kU/L, focusing on the prevalence of atopic and non-atopic conditions, the aetiology of extremely elevated TS-IgE and the relevance of TS-IgE levels for the diagnosis of non-atopic diseases.

Methods

Data from paediatric patients managed at HUS Group hospitals in Finland between 1998 and 2024 were queried for TS-IgE levels and International Classification of Diseases (ICD)-10 diagnostic codes. A chart review was performed for patients with non-atopic conditions.

Results

Our cohort included 2431 children with TS-IgE levels over

SUBMITTER: Arola A 

PROVIDER: S-EPMC12520262 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature