The Association Between Clinically Diagnosed Neonatal Jaundice and Autism: A Swedish Register-Based Cohort Study.

ABSTRACT:

Aim

Neonatal jaundice may increase the likelihood of autism through its influence on neurodevelopment. We assessed whether neonatal jaundice increases the risk for autism while accounting for confounding of perinatal risk factors.

Method

We used a population-based cohort of 1 669 830 individuals born in Sweden between 1992 and 2010. Information on jaundice and autism was retrieved from Swedish registers. Participants were followed from the age of 3, with available follow-up until 2013. We used Cox regression to estimate the hazard ratios (HRs) relating autism to neonatal jaundice.

Results

Prior to accounting for covariates such as prenatal and perinatal factors, we observed an association between neonatal jaundice and autism (HR = 1.48, 95% CI: 1.37-1.60). This associ

SUBMITTER: Kanina A 

PROVIDER: S-EPMC12520264 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature