Clonal hematopoiesis and subsequent venous thromboembolism among survivors of autologous transplantation for lymphoma.

ABSTRACT: Clonal hematopoiesis is associated with increased risk of venous thromboembolism (VTE). The risk of VTE is high in patients with lymphoma and after autologous peripheral blood stem cell transplantation, and clonal hematopoiesis is present in many patients with lymphoma at autologous peripheral blood stem cell transplantation. We examined whether clonal hematopoiesis increases posttransplant VTE risk in patients with lymphoma. Our study included 557 patients with lymphoma who had survived 2 or more years after receiving autologous peripheral blood stem cell transplantation between 1999 and 2014. Clonal hematopoiesis was measured by targeted sequencing of cryopreserved peripheral blood stem cell product. Median age at stem cell transplantation was 54 years. Subdistribution hazard regression

SUBMITTER: Gangaraju R 

PROVIDER: S-EPMC12520326 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature