Synergistic effects of sesame oil, extra virgin olive oil, psyllium extract, and dandelion extract on cholesterol gallstone dissolution: An in vitro comparative study against Rowachol®.

ABSTRACT:

Background

Cholesterol gallstones represent a significant global health burden. Current treatments, including surgery and oral dissolution agents, are often invasive or limited by side effects and variable efficacy. This study investigated the in vitro gallstone-dissolving efficacy of a natural combination-sesame oil (SO), extra virgin olive oil (EVOO), psyllium extract (PE), and dandelion extract (DE)-compared to the pharmaceutical agent Rowachol®.

Methods

In a randomized in vitro study, seventy cholesterol-dominant human gallstones were assigned to seven groups receiving either individual agents, multi-component combinations, or Rowachol® (control). Two prespecified endpoints were assessed under standardized simulated bile conditions at 48 h (T1), 96 h (T2), and 144 h (T3)

SUBMITTER: Serri R 

PROVIDER: S-EPMC12520339 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature