β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator.

ABSTRACT:

Introduction

β-Nicotinamide adenine dinucleotide (β-NAD) is recognized as a sympathetic neurotransmitter that relaxes vascular and intestinal smooth muscle through purinergic receptor pathways. In the lung, β-NAD has been associated with anti-inflammatory effects, but its role in regulating airway smooth muscle tone remains unexplored. This study investigates the impact of β-NAD on airway smooth muscle and elucidates the underlying mechanisms of its action.

Materials and methods

Airway constriction was assessed as a force in organ bath (mouse trachea, human bronchioli) and as a luminal area in mouse precision-cut lung slices. The latter was combined with recording changes in [Ca2+] and membrane potential. Intracellular calcium and cyclic AMP concentrations were recorded in i

SUBMITTER: Jurastow I 

PROVIDER: S-EPMC12520353 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature