Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators.

ABSTRACT: Thoracic aortic aneurysms (TAAs) stem from diverse mechanical and mechanobiological disruptions to the aortic wall that can also increase the risk of dissection or rupture. There is increasing evidence that dysfunctions along the aortic mechanotransduction axis, including reduced integrity of elastic fibers and loss of cell-matrix connections, are particularly capable of causing thoracic aortopathy. Because different insults can produce distinct mechanical vulnerabilities, there is a pressing need to identify interacting factors that drive progression. In this work, we employ a finite element framework to generate synthetic TAAs arising from hundreds of heterogeneous insults that span a range of compromised elastic fiber integrity and cellular mechanosensing. From these simulations, we con

SUBMITTER: Li DS 

PROVIDER: S-EPMC12520381 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature