The impact of pulsatile vs. non-pulsatile perfusion in patients undergoing cardiopulmonary bypass: A comprehensive systematic review and meta-analysis of 33 randomized controlled trials.

ABSTRACT:

Background

Pulsatile perfusion is a developing technique that attempts to mimic the natural pulsatile flow of blood during cardiopulmonary bypass (CBP).

Purpose

This systematic review and meta-analysis was conducted to show the effects of pulsatile perfusion in CPB compared to non-pulsatile.

Methods

Randomized control trials that evaluated the implementation of pulsatile perfusion during cardiopulmonary bypass surgery were identified by a literature search in the following electronic databases (PubMed, Web of Science, Scopus, CENTRAL, and Embase) published from inception up to February 2024.

Results

The search yielded 33 trials of which three studies demonstrated a low risk of bias, 29 studies showed some concerns, and one study presented a high risk of bias ov

SUBMITTER: Abdelraouf MR 

PROVIDER: S-EPMC12520390 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature