Estimation the Maximum Tolerance Activity of Blood by a Simple Algorithm Method in Pediatric Differentiated Thyroid Cancer Patients Treated With Empirical Radioactive Iodine Dosing Based on Risk Stratification.

ABSTRACT: After total thyroidectomy for pediatric differentiated thyroid cancer (DTC), the subsequent radioactive iodine (RAI) treatment is a robust therapy, the dosing of which is a major concern. This study was designed to evaluate the "as high as safe administration" (AHASA) principle of RAI treatment in pediatric DTC patients based on the maximum tolerance activity (MTA) of blood to certify dosimetry via a simple algorithm method. Twenty pediatric DTC patients were enrolled and received RAI treatment empirical dosing based on risk stratification after total thyroidectomy. The MTA concentration in the blood was estimated by the modified Hänscheid equation. About 6 (30%) patients had tumors larger than 4 cm, 10 (50%) patients had lateral cervical lymph node metastasis, and 4 (20%) patients had rec

SUBMITTER: Chen YW 

PROVIDER: S-EPMC12520466 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature