Dysfunctional Decidual CD4⁺T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation.

ABSTRACT: Palmitoylation is a fully reversible post-translational modification that regulates the functions of various proteins. While its dysregulation has been implicated in numerous pathological processes, there has been scarce researches on palmitoylation changes in proteins associated with recurrent pregnancy loss (RPL). Utilizing palmitoylation proteomics, 3262 proteins are identified with increased palmitoylation and 1577 proteins with decreased palmitoylation in the decidual immune cells from RPL patients compared to those from normal early pregnancies. Reduced palmitoylation by 2-bromopalmitate promoted decidual CD4⁺T (dCD4⁺T) cell tolerance and decrease the resorption rate of abortion-prone mice, suggesting that elevated palmitoylation level may be associated with RPL

SUBMITTER: Cui L 

PROVIDER: S-EPMC12520500 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature