Akkermansia muciniphila-Derived N-Acetylspermidine Modulates the Localization of Intestinal α1,2-Fucosylated Proteins to Maintain Gut Homeostasis.

ABSTRACT: The growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2-fucosylation-enhancing strategies shows significant potential as a colitis treatment modality by promoting gut homeostasis. Although certain probiotics alleviate colitis by enhancing intestinal α1,2-fucosylation, the molecular mechanisms by which probiotics-derived metabolites modulate this process remain unclear. This study found that the probiotic Akkermansia muciniphila (A. muciniphila) enhanced intestinal α1,2-fucosylation, a crucial factor contributing to its colitis-alleviating effects. Specifically, A. muciniphila-derived N-acetylspermidine upregulated α1,2-fucosylation, thereby enhancing barrier integrity and supp

SUBMITTER: Yao Y 

PROVIDER: S-EPMC12520552 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature