Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells.

ABSTRACT: Schwann cells are pivotal in generating a pro-regenerative microenvironment for long-gap peripheral nerve injury (PNI) repair via their orchestrated behaviors, including cell migration, proliferation, and secretion. Bioceramics can release bioactive ions to regulate "repair" cells for regenerating damaged tissues. Herein, bioceramic akermanite (AT) is screened and found to significantly enhance Schwann cell proliferation, migration, and secretion by activating the PI3K/AKT and MAPK/ERK signaling pathways. Integration with silk sericin (SS), a natural biomaterial possessing excellent bioactivity, promotes the release of Ca and Mg from AT, synergistically enhancing Schwann cell pro-regenerative behaviors and accelerating axon elongation. The AT-SS composite conduit effectively restores nerve

SUBMITTER: Su Q 

PROVIDER: S-EPMC12520579 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature