HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos.

ABSTRACT: Human fertility is suboptimal in part by error-prone divisions during early cleavage stages, which frequently result in chromosomal aneuploidy. Most human pre-implantation embryos are mosaics of euploid and aneuploid cells, yet those with a low proportion of aneuploid cells can develop to term at rates similar to fully euploid embryos. How embryos manage aneuploidy during early development remains poorly understood - yet this knowledge is crucial for improving fertility outcomes and reducing developmental defects. To investigate these mechanisms, we established a new mouse model of chromosome mosaicism to trace the fate of aneuploid cells during pre-implantation development. We previously used the Mps1 inhibitor reversine to induce aneuploidy. Here, we demonstrate that the more specific Mp

SUBMITTER: Sanchez-Vasquez E 

PROVIDER: S-EPMC12520657 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature