Homeostatic synaptic plasticity of miniature excitatory postsynaptic currents in mouse cortical cultures requires neuronal <i>Rab3a</i>.

ABSTRACT: Following prolonged activity blockade, amplitudes of miniature excitatory postsynaptic currents (mEPSCs) increase, a form of plasticity termed 'homeostatic synaptic plasticity'. We previously showed that a presynaptic protein, the small GTPase Rab3a, is required for full expression of the increase in miniature endplate current amplitudes following prolonged blockade of action potential activity at the mouse neuromuscular junction (NMJ) in vivo, where an increase in postsynaptic receptors does not contribute. It is unknown whether this form of Rab3a-dependent homeostatic plasticity at the NMJ shares any characteristics with central synapses. We show here that homeostatic synaptic plasticity of mEPSCs is impaired in mouse cortical neuron cultures prepared from Rab3a

SUBMITTER: Koesters AG 

PROVIDER: S-EPMC12520659 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature