Gene Expression in Urinary Sediment Cells as an Indicator of the Contribution of Plasma Lipids to Diabetic Kidney Disease.

ABSTRACT:

Background

In individuals with Type 1 diabetes mellitus (T1D) who maintain good glycemic control and are free of chronic complications, lipid profiles are generally within normal ranges. However, impaired renal function or albuminuria alters this profile, contributing to the progression of diabetic kidney disease (DKD). This study hypothesized that, in urinary sediment cells from T1D individuals (n = 87), the mRNA expression of genes related to free fatty acid (FFA) uptake (CD36, FABP1, SCL27A1, SLC27A2, and SLC27A4, which encode FATP1, FATP2, and FATP4, respectively), albumin uptake (LRP2 and CUBN), inflammation (IL1B and IL18), and fibrosis (TGFB1) would vary depending on the degree

SUBMITTER: Zocchio TT 

PROVIDER: S-EPMC12520818 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature